Integrin Signaling in Leukocytes

1. Abstract 2. Introduction 3. Discussion 3.1. β2 integrin engagement induces activation of tyrosine kinases 3.1.1 Activation of src family tyrosine kinases 3.1.2. Activation of Syk 3.1.3. Activation of tyrosine kinases of the FAK family 3.2. Proteins that are tyrosine phosphorylated upon β2 integrin engagement in leukocytes 3.2.1. The docking protein Cbl 3.2.2. The guanine nucleotide exchange factor Vav 3.2.3. p190RhoGAP and p120RasGAP 3.3. Activation of phosphoinositide 3-kinase by β2 integrins 3.3.1. Association of PI 3-kinase with β2 integrins 3.3.2. Association of PI 3-kinase with docking proteins 3.3.3. Association of PI 3-kinase with src tyrosine kinases 3.3.4. Association of PI 3-kinase with small GTP-binding proteins 3.4. Possible cross-talk between the β2 integrins and the insulin/IGF-I signaling pathway 3.5. β2 integrins regulate the small GTP-binding proteins Ras and RhoA 3.5.1. β2 integrins regulate Ras in PMNs 3.5.2. β2 integrins regulate RhoA in PMNs 3.6. Calcium signaling 3.6.1. Phospholipase C-γ is involved in the β2 integrin-induced Ca signal 3.6.2. Tyrosine kinases are required for the β2 integrin-induced Ca signal 3.6.3. Involvement of PKC in β2 integrin signaling 3.6.4. Role of the cytoskeleton in β2 integrin signaling 4. Acknowledgements 5. Perspectives 6. References